Nefropatías intersticiales
Ester González Monte
Médico Adjunto del Servicio de Nefrología. Hospital Universitario 12 de Octubre. Madrid, Madrid (España)

1. Introducción

2. Nefropatías intersticiales agudas

2.1. Definición y etiología

2.2. Patogenia 

2.3. Anatomía patológica 

2.4. Manifestaciones clínicas 

2.5. Tratamiento de la nefritis intersticial aguda inducida por fármacos

2.6. Tratamiento de otros tipos de nefritis intersticial aguda

3. Nefropatías intersticiales crónicas

3.1. Etiología

3.2. Anatomía patológica

3.3. Manifestaciones clínicas

3.4. Tratamiento de otros tipos de nefropatía intersticial crónica

4. Bibliografía recomendada

Introducción


Bajo el término de nefropatías intersticiales se engloban aquellas enfermedades que afectan de forma predominante al intersticio renal. Aunque pueden encontrarse afectos en mayor o menor medida todos los integrantes del parénquima renal (glomérulos, túbulos, intersticio y vasos), se requiere que la agresión patogénica y la mayor lesión estructural se localicen en el intersticio para calificar como intersticial una determinada afección renal. Dado que las células del túbulo renal presentan anomalías histológicas y funcionales en todas las nefropatías intersticiales, algunos autores prefieren utilizar el término de nefropatías tubulointersticiales.


Referencias Bibliográficas

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23. Abed L, Merouani A, Haddad E. Presence of autoantibodies against tubular and uveal cells in a patient with tubulointerstitial nephritis and uveitis (TINU) syndrome. Nephrol Dial Transplant 2008; 23: 1452-1455. [PubMed]

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Tablas
Tabla 1. Etiología de las nefropatías intersticiales agudas
Tabla 2. Características de presentación clínica y de laboratorio en pacientes con nefritis intersticial aguda
Tabla 3. Etiología de las nefropatías intersticiales crónicas

Figuras

Figura 1. Infiltrado intersticial celular

Figura 2. Fibrosis intersticial y atrofia tubular